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首页-小分子抑制剂&激动剂-Autophagy-Lucanthone
Lucanthone

Chemical Structure : Lucanthone

CAS No.: 479-50-5

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Lucanthone

货号: PC-60602Not For Human Use, Lab Use Only.

Lucanthone is an ionizing radiation enhancer and apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor with IC50 of 5 uM for inhibition of APE1 incision of depurinated plasmid DNA, also may act as an inhibitor of protein palmitoyl thioesterase 1 (PPT1).

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25 mg ￥2580 In stock
50 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lucanthone is an ionizing radiation enhancer and apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor with IC50 of 5 uM for inhibition of APE1 incision of depurinated plasmid DNA, also may act as an inhibitor of protein palmitoyl thioesterase 1 (PPT1).
Lucanthone slows GBM by inhibiting autophagic flux through lysosome targeting and decreases the number of Olig2+ glioma stem-like cells (GSC) in vitro and in vivo.
Lucanthone efficiently abates stemness in patient-derived GSC and reduces tumor microtube formation in GSC, an emerging hallmark of treatment resistance in GBM.
Lucanthone is an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) potential antineoplastic activity, also inhibits autophagy; induces lysosomal membrane permeabilization, and possesses significantly more potent activity in breast cancer models compared with chloroquine; induces cathepsin D-mediated apoptosis.

物理化学性质&存储条件

分子量 340.485
分子式 C20H24N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl- (6CI,8CI)

参考文献

1. Carew JS, et al. J Biol Chem. 2011 Feb 25;286(8):6602-13.

2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.

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