Lubiprostone | Chloride channel activator | Probechem Biochemicals

Chemical Structure : Lubiprostone

CAS No.: 136790-76-6

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Lubiprostone (RU-0211, SPI-0211)

货号: PC-25678Not For Human Use, Lab Use Only.

Lubiprostone (SPI-0211) is a potent, selective type 2 chloride channel (CLC-2) activator, increases electrogenic Cl- transport across the apical membrane of T84 cells with EC50 of 18 nM.

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生物&药学活性

Lubiprostone (SPI-0211) is a potent, selective type 2 chloride channel (CLC-2) activator, increases electrogenic Cl- transport across the apical membrane of T84 cells with EC50 of 18 nM.
Lubiprostone (SPI-0211) activates ClC-2 Cl- currents in HEK293 cell line stably transfected with either recombinant human ClC-2 measured by whole cell patch clamp with EC50 of 17 nM.
Lubiprostone (SPI-0211) shows no effect on CFTR Cl- channel currents measured in CFTR-transfected HEK-293 cells.
Lubiprostone (SPI-0211) induces the passive movement of sodium and water into the intestinal lumen, yielding a net increase in isotonic fluid, induces intestinal secretion.

物理化学性质&存储条件

分子量	390.47
分子式	C20H32F2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((1R,2R,3R)-2-(4,4-Difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid

参考文献

1. Camilleri M, et al. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G942-7.

Lubiprostone (RU-0211, SPI-0211)

生物&药学活性

物理化学性质&存储条件

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Lubiprostone (RU-0211, SPI-0211)

生物&药学活性

物理化学性质&存储条件

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