Lu AF60097 | SERT inhibitor | Probechem Biochemicals

Chemical Structure : Lu AF60097

加入收藏

Lu AF60097 (Lu AF 60097)

货号: PC-20763Not For Human Use, Lab Use Only.

Lu AF60097 is a high affinity, allosteric inhibitor of serotonin transporter (SERT) inhibitor with IC50 of 31 nM for inhibition of [3H]IMI dissociation, targets the extracellular vestibule (S2 site).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Lu AF60097 is a high affinity, allosteric inhibitor of serotonin transporter (SERT) inhibitor with IC50 of 31 nM for inhibition of [3H]IMI dissociation, targets the extracellular vestibule (S2 site).
Lu AF60097 inhibited [3H]5-HT uptake with an IC50 of 207 nM in hSERT expressed in COS-7 cells.
Lu AF60097 and imipramine can block SERT synergistically.
Lu AF60097 (250 nM) increases hippocampal 5-HT levels in rat hippocampus.

物理化学性质&存储条件

分子量	525.62
分子式	C32H32FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC2=C([C@](CCCN3CCC(C4=CC5=C(C=C4)C=CC(N5)=O)CC3)(C6=CC=C(F)C=C6)OC2)C=C1)N

参考文献

1. Per Plenge, et al. Nature Communications volume 11, Article number: 1491 (2020)

Lu AF60097 (Lu AF 60097)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Lu AF60097 (Lu AF 60097)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.