Lu AF-58027 |CAS:1255919-63-1 Probechem Biochemicals

Chemical Structure : Lu AF-58027

加入收藏

Lu AF-58027 (Lu AF58027)

货号: PC-61343Not For Human Use, Lab Use Only.

Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively.
Lu AF-58027 shows no signigicant inhibitory effects at other PDEs (at least micromolar concentrations).
Lu AF-58027 induces concentration-dependent relaxations reduced by ODQ and SQ22536 in rat isolated mesenteric arteries.
Lu AF-58027 dose-dependently lowers mean BP and increases heart rate in anaesthetized rats.

物理化学性质&存储条件

分子量	486.62
分子式	C28H34N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-isobutyl-5-methyl-2-(4-(1-methylpyrrolidin-2-yl)benzyl)-3-(phenylamino)-2,7-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione

参考文献

1. Laursen M, et al. Br J Pharmacol. 2017 Aug;174(15):2563-2575.

Lu AF-58027 (Lu AF58027)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Lu AF-58027 (Lu AF58027)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.