Lotixparib (DM5167) | PARP1 inhibitor | Probechem Biochemicals

Chemical Structure : Lotixparib

CAS No.: 2640677-63-8

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Lotixparib (DM5167, DM-5167)

货号: PC-25071Not For Human Use, Lab Use Only.

Lotixparib (DM5167) is a potent, selective PARP1 inhibitor with IC50 of 0.41 nM, displays >300-fold preference for PARP1 over PARP2 in in vitro enzymatic and DNA capture assays.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Lotixparib (DM5167) is a potent, selective PARP1 inhibitor with IC50 of 0.41 nM, displays >300-fold preference for PARP1 over PARP2 in in vitro enzymatic and DNA capture assays.

DM5167 shows higher selectivity than AZD5305 in the enzymatic assay.

DM5167 efficiently reduces growth of triple-negative breast cancers.

DM5167 achieved a 45.8% tumor growth inhibition at a dose of 50 mg/kg in orthotopic xenograft model using triple-negative breast cancer cell lines.

物理化学性质&存储条件

分子量	390.46
分子式	C23H23FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(3-(8-fluoro-1-oxo-1,2-dihydroisoquinolin-3-yl)propyl)piperazin-1-yl)benzonitrile

参考文献

1. Patent WO2021086077 A1.
2. Kim JW, et al. Pharm Res. 2025 Oct 22. doi: 10.1007/s11095-025-03939-8.
3. Sujin Nam, et al. Cancer Res (2023) 83 (7_Supplement): 509.

Lotixparib (DM5167, DM-5167)

生物&药学活性

物理化学性质&存储条件

参考文献

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Lotixparib (DM5167, DM-5167)

生物&药学活性

物理化学性质&存储条件

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