Lotamilast |CAS:947620-48-6 Probechem Biochemicals

Chemical Structure : Lotamilast

CAS No.: 947620-48-6

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Lotamilast (RVT 501;E6005)

货号: PC-61387Not For Human Use, Lab Use Only.

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.

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5 mg	￥980	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.
Lotamilast (RVT 501, E6005) produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application.
Lotamilast (RVT 501, E6005) ameliorates the appearance of atopic dermatitis-like skin lesions in AD models.

物理化学性质&存储条件

分子量	472.501
分子式	C26H24N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate

参考文献

1. Ishii N, et al. J Pharmacol Exp Ther. 2013 Jul;346(1):105-12.

2. Andoh T, et al. Exp Dermatol. 2014 May;23(5):359-61.

3. Kubota S, et al. Eur J Pharmacol. 2015 Dec 5;768:41-8.

4. Furue M, et al. Expert Opin Investig Drugs. 2017 Dec;26(12):1403-1408.

Lotamilast (RVT 501;E6005)

生物&药学活性

物理化学性质&存储条件

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Lotamilast (RVT 501;E6005)

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物理化学性质&存储条件

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