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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FLT3-Lomonitinib
Lomonitinib

Chemical Structure : Lomonitinib

CAS No.: 2923221-56-9

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Lomonitinib (ZE46-0134)

货号: PC-24149Not For Human Use, Lab Use Only.

Lomonitinib (ZE46-0134) is a highly potent and selective pan-FLT3/IRAK4 inhibitor, targets clinically relevant FLT3 mutations (ITD, TKD) including the gatekeeper mutation, as well as IRAK4, a putative escape pathway for FLT3-driven acute myeloid leukemia (AML).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Lomonitinib (ZE46-0134) is a highly potent and selective pan-FLT3/IRAK4 inhibitor, targets clinically relevant FLT3 mutations (ITD, TKD) including the gatekeeper mutation, as well as IRAK4, a putative escape pathway for FLT3-driven acute myeloid leukemia (AML).

物理化学性质&存储条件

分子量 436.52
分子式 C27H24N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3,4-dimethoxyphenyl)-1-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1H-pyrazolo[4,3-c]quinoline

参考文献

1. Patent WO2023064133 A1.

2. Tara L. Lin, et al. Blood (2024) 144 (Supplement 1): 2883.4.

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