Lomibuvir | HCV NS5B inhibitor | Probechem Biochemicals

Chemical Structure : Lomibuvir

CAS No.: 1026785-59-0

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Lomibuvir (VX-222, VCH-222)

货号: PC-45961Not For Human Use, Lab Use Only.

Lomibuvir (VX-222, VCH-222) is a potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Lomibuvir (VX-222, VCH-222) is a potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM.
Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with EC50 of 17 nM, the M423I and A486S variants remaine susceptible to VX-222.
Lomibuvir exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2 uM, respectively.
Lomibuvir displays fine pharmacokinetic proﬁle in rats and dogs.

物理化学性质&存储条件

分子量	445.6147
分子式	C25H35NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-

参考文献

1. Yi G, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):830-7.

2. Jiang M, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5456-65.

3. Di Bisceglie AM, et al. Eur J Gastroenterol Hepatol. 2014 Jul;26(7):761-73.

Lomibuvir (VX-222, VCH-222)

生物&药学活性

物理化学性质&存储条件

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Lomibuvir (VX-222, VCH-222)

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物理化学性质&存储条件

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