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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-Lockdown Ester Prodrug
Lockdown Ester Prodrug

Chemical Structure : Lockdown Ester Prodrug

CAS No.: 2985814-80-8

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Lockdown Ester Prodrug (Lockdown Pro)

货号: PC-38405Not For Human Use, Lab Use Only.

Lockdown Ester Prodrug (Lockdown Pro) is the ester-modified Lockdown with increased membrane permeability and prodrug-like properties, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Lockdown Ester Prodrug (Lockdown Pro) is the ester-modified Lockdown with increased membrane permeability and prodrug-like properties, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion.
    Lockdown Ester Prodrug (Lockdown Pro) effectively block PPM1F-mediated effects on integrin β1 and PAK in cells, Lockdown Pro suppresses tissue invasion by PPM1F-overexpressing human cancer cells.

    物理化学性质&存储条件

    分子量 668.739
    分子式 C39H40O10
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    tetraethyl 4,4'-((propane-2,2-diylbis(4,1-phenylene))bis(oxy))diphthalate

    参考文献

    1. Grimm TM, et al. Cell Chem Biol. 2022 Apr 15:S2451-9456(22)00128-3.

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