Lockdown | PPM1F inhibitor | Probechem Biochemicals

Chemical Structure : Lockdown

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Lockdown (PPM1F inhibitor Lockdown)

货号: PC-38404Not For Human Use, Lab Use Only.

Lockdown is a selective, reversible and non-competitive inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion.

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生物&药学活性

Lockdown is a selective, reversible and non-competitive inhibitor of the integrin phosphatase PPM1F (IC50=16.37 uM), blocks cancer cell invasion.
Lockdown acts in a dose-dependent, allosteric manner with high selectivity for PPM1F.
Lockdown does not inhibit other protein phosphatases (PTP1P, PTPRJ, PP5) in vitro and does not induce additional phenotypes in PPM1F knockout cells.
Lockdown fully re-capitulated the phenotype of PPM1F-deficient cells, increased phosphorylation of PPM1F substrates and corruption of integrin-dependent cellular processes in Lockdown treated glioblastoma cells.
Phosphatase PPM1F is a regulator of cell adhesion by fine-tuning integrin activity and actin cytoskeleton structures. Elevated expression of this enzyme in human tumors is associated with high invasiveness, enhanced metastasis, and poor prognosis.

物理化学性质&存储条件

分子量	556.523
分子式	C31H24O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-((propane-2,2-diylbis(4,1-phenylene))bis(oxy))diphthalic acid

参考文献

1. Grimm TM, et al. Cell Chem Biol. 2022 Apr 15:S2451-9456(22)00128-3.

Lockdown (PPM1F inhibitor Lockdown)

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物理化学性质&存储条件

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Lockdown (PPM1F inhibitor Lockdown)

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