Loberamisal (ZL006-05)

Chemical Structure : Loberamisal

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货号: PC-28216Not For Human Use, Lab Use Only.

Loberamisal (ZL006-05) is a small-molecule compound that dually targets the postsynaptic density 95 (PSD-95) pathway and α2 γ-aminobutyric acid type α (α2-GABAA) receptor, disrupts PSD-95-nNOS interaction and selectively potentiates α2-containing GABAAR.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Loberamisal (ZL006-05) is a small-molecule compound that dually targets the postsynaptic density 95 (PSD-95) pathway and α2 γ-aminobutyric acid type α (α2-GABAA) receptor, disrupts PSD-95-nNOS interaction and selectively potentiates α2-containing GABAAR.
ZL006-05 is highly effective against chronic pain without analgesic tolerance and side effects.
ZL006-05 not only abolish the SNL-induced increase in PSD-95-nNOS complex in the SDH but also show a very high affinity to α2-containing GABAAR.
ZL006-05 can avoid analgesic tolerance and unwanted side effects.

物理化学性质&存储条件

分子量	464.38
分子式	C24H27Cl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,4R)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoate

参考文献

1. Li J, et al. Theranostics. 2021 Apr 3;11(12):5970-5985.

2. Wei W, et al. Neurotherapeutics. 2021 Oct;18(4):2436-2448.

3. Feng B, et al. Stroke Vasc Neurol. 2026 Aug 27;11(4):465-472.