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首页-小分子抑制剂&激动剂-Others-Other Targets-Lixumistat
Lixumistat

Chemical Structure : Lixumistat

CAS No.: 1422365-93-2

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Lixumistat (HL156A, IM156, IM-156)

货号: PC-49735Not For Human Use, Lab Use Only.

IM156 (Lixumistat, HL156A, IM-156) is a metformin derivative and potent biguanide OXPHOS inhibitor of Protein Complex 1 (PC1) of the mitochondrial electron transport chain, also shows higher potency of AMPK activation than metformin.

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25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IM156 (Lixumistat, HL156A, IM-156) is a metformin derivative and potent biguanide OXPHOS inhibitor of Protein Complex 1 (PC1) of the mitochondrial electron transport chain, also shows higher potency of AMPK activation than metformin.
HL156A, combined with TMZ, inhibited the stemness of GMB tumorspheres.
Combined treatment with HL156A and TMZ showed survival benefits in an orthotopic xenograft mouse model.
IM156 (HL156A) prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways.
IM156 (HL156A) suppressed AT84 mouse oral tumor growth, accompanied by down-regulated p-IGF-1, p-mTOR, proliferating cell nuclear antigen (PCNA) and promoted p-AMPK and TUNEL expression.

物理化学性质&存储条件

分子量 315.30
分子式 C13H16F3N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(N-(4-(trifluoromethoxy)phenyl)carbamimidoyl)pyrrolidine-1-carboximidamide

参考文献

1. Izreig S, et al. Cell Rep Med. 2020 May 19;1(2):100014.

2. Willette RN, et al. J Pharmacol Exp Ther. 2021 Nov;379(3):290-300.

3. Choi J, et al. Oncotarget. 2016;7:65643–65659.

4. Lam TG, et al. Cancer Sci. 2018;109:699–709.

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