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Liproxstatin-1

Chemical Structure : Liproxstatin-1

CAS No.: 950455-15-9

Liproxstatin-1 (Liproxstatin 1)

货号: PC-43164Not For Human Use, Lab Use Only.

Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis.
Liproxstatin-1 prevents BODIPY 581/591 C11 oxidation in Gpx4−/− cells, does not interfere with other classical types of cell death, such as TNFα-induced apoptosis and H2O2-induced necrosis.
Liproxstatin-1 suppresses ferroptosis in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.

物理化学性质&存储条件

分子量 340.8499
分子式 C19H21ClN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-

参考文献

1. Friedmann Angeli JP, et al. Nat Cell Biol. 2014 Dec;16(12):1180-91.

2. Kim SE, et la. Nat Nanotechnol. 2016 Nov;11(11):977-985.

3. Zilka O, et al. ACS Cent Sci. 2017 Mar 22;3(3):232-243.

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