Lipofermata |CAS:297180-15-5 Probechem Biochemicals

Chemical Structure : Lipofermata

CAS No.: 297180-15-5

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Lipofermata (CB16.2 aka)

货号: PC-35366Not For Human Use, Lab Use Only.

Lipofermata (CB16.2 aka) is a specific fatty acid transport (FATP) inhibitor, blocks human FATP2-mediated fatty acid uptake (IC50=4.84 uM in Caco-2 cells) without impacting other cellular functions.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Lipofermata (CB16.2 aka) is a specific fatty acid transport (FATP) inhibitor, blocks human FATP2-mediated fatty acid uptake (IC50=4.84 uM in Caco-2 cells) without impacting other cellular functions.
Lipofermata demonstrates cellualr transport inhibition activity models for myocytes (mmC2C12), pancreatic β-cells (rnINS-1E), intestinal epithelial cells (hsCaco-2), and hepatocytes (hsHepG2), as well as primary human adipocytes, which is specific for long and very long chain fatty acids but has no effect on medium chain fatty acids (C6-C10).
Lipofermata also abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.

物理化学性质&存储条件

分子量	360.229
分子式	C15H10BrN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-bromo-5'-phenylspiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-one

参考文献

1. Ahowesso C, et al. Biochem Pharmacol. 2015 Nov 1;98(1):167-81.

2. Black PN, et al. Medchemcomm. 2016 Apr 1;7(4):612-622.

3. Zhang M, et al. Cancer Discov. 2018 Jun 14. pii: CD-17-1371.

4. Sandoval A, et al. Biochem Pharmacol. 2010 Apr 1;79(7):990-9.

Lipofermata (CB16.2 aka)

生物&药学活性

物理化学性质&存储条件

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Lipofermata (CB16.2 aka)

生物&药学活性

物理化学性质&存储条件

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