Linopirdine dihydrochloride |CAS:113168-57-3 Probechem Biochemicals

Chemical Structure : Linopirdine dihydrochloride

CAS No.: 113168-57-3

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Linopirdine dihydrochloride (DUP-996 dihydrochloride)

货号: PC-63068Not For Human Use, Lab Use Only.

Linopirdine (DUP-996) dihydrochloride is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

Linopirdine (DUP-996) dihydrochloride is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker.
Linopirdine blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
Linopirdine inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.

物理化学性质&存储条件

分子量	464.39
分子式	C26H21N3O.2HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one

参考文献

1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17.

2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3.

3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Linopirdine dihydrochloride (DUP-996 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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Linopirdine dihydrochloride (DUP-996 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

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