Lifitegrast (SAR1118) | LFA-1/ICAM-1 inhibitor | Probechem Biochemicals

Chemical Structure : Lifitegrast

CAS No.: 1025967-78-5

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Lifitegrast (SAR1118, SAR-1118, SHP-606)

货号: PC-45616Not For Human Use, Lab Use Only.

Lifitegrast (SAR1118) is a potent LFA-1/ICAM-1 antagonist with IC50 of 9 nM in HuT78 cells.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

Lifitegrast (SAR1118) is a potent LFA-1/ICAM-1 antagonist with IC50 of 9 nM in HuT78 cells.
Lifitegrast (SAR1118) exhibits good in vitro safety profile and low potency on CYP3A4, CYP2C9 and hERG.
Lifitegrast (SAR1118) is under development as an ophthalmic solution for treating dry eye.

物理化学性质&存储条件

分子量	615.4811
分子式	C29H24Cl2N2O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-

参考文献

1. Zhong M, et al. ACS Med Chem Lett. 2012 Jan 31;3(3):203-6.

2. Sun Y, et al. J Ocul Pharmacol Ther. 2013 May;29(4):395-402.

3. Semba CP, et al. Clin Ophthalmol. 2016 Jun 10;10:1083-94.

Lifitegrast (SAR1118, SAR-1118, SHP-606)

生物&药学活性

物理化学性质&存储条件

参考文献

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Lifitegrast (SAR1118, SAR-1118, SHP-606)

生物&药学活性

物理化学性质&存储条件

参考文献

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