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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-Licochalcone E
Licochalcone E

Chemical Structure : Licochalcone E

CAS No.: 864232-34-8

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Licochalcone E (LicoE)

货号: PC-23581Not For Human Use, Lab Use Only.

Licochalcone E (LicoE) is a glycyrrhiza-inflata-derived chalcone, exhibits potent anti-inflammatory properties inhibits Aβ1-42 aggregation and activates Nrf2, also inhibits pancreatic lipase (PL) with IC50 of 5.8 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Licochalcone E (LicoE) is a glycyrrhiza-inflata-derived chalcone, exhibits potent anti-inflammatory properties inhibits Aβ1-42 aggregation and activates Nrf2, also inhibits pancreatic lipase (PL) with IC50 of 5.8 uM.
Licochalcone E displays high efficiency against methicillin-resistant Staphylococcus aureus (MRSA).
Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells.
Licochalcone E suppresses lung metastasis in the 4T1 mammary orthotopic cancer model.
Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway.

物理化学性质&存储条件

分子量 338.40
分子式 C21H22O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S,E)-3-(4-Hydroxy-2-methoxy-5-(3-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

参考文献

1. Kim SS, et al. J Nutr Biochem. 2012 Oct;23(10):1314-23.

2. Zhou T, et al. J Microbiol Biotechnol. 2012 Jun;22(6):800-5.

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