Licochalcone B

Chemical Structure : Licochalcone B

CAS No.: 58749-23-8

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货号: PC-23579Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Licochalcone B is an extract from the root of Glycyrrhiza uralensis, inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduces metal-induced Aβ42 aggregation through chelating metal ions.
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
Licochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway.
Licochalcone B inhibits growth and induces apoptosis of NSCLC cells.

物理化学性质&存储条件

分子量	286.28
分子式	C16H14O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

参考文献

1. Cao Y, et al. Nat Prod Res. 2018 Oct 22:1-4.

2. Jun-ichi Furusawa, et al. Int Immunopharmacol. 2009 Apr;9(4):499-507.

3. Ha-Na Oh, et al. Phytomedicine. 2019 Oct;63:153014.

Licochalcone B

生物&药学活性

物理化学性质&存储条件

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Licochalcone B

生物&药学活性

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