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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Complement System-Licancopan fumarate
Licancopan fumarate

Chemical Structure : Licancopan fumarate

CAS No.: 3024486-04-9

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Licancopan fumarate (HRS-5965, HRS5965)

货号: PC-28511Not For Human Use, Lab Use Only.

Licancopan fumarate (HRS-5965) is a potent, selective and orally active complement factor (Factor B) inhibitor, disrupts the formation of C3 convertases within the alternative pathway, thereby halting C3 cleavage and downstream complement activation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Licancopan fumarate (HRS-5965) is a potent, selective and orally active complement factor (Factor B) inhibitor, disrupts the formation of C3 convertases within the alternative pathway, thereby halting C3 cleavage and downstream complement activation.

物理化学性质&存储条件

分子量 564.64
分子式 C31H36N2O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((1S,3S,5R)-3-ethoxy-8-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)-8-azabicyclo[3.2.1]octan-1-yl)benzoic acid fumarate

参考文献

1. Patent WO2022143845 A1.

2. Xu Y, et al. Med. 2025 Aug 8;6(8):100698.

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