Libvatrep (SAF312)

Chemical Structure : Libvatrep

CAS No.: 871814-52-7

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货号: PC-38676Not For Human Use, Lab Use Only.

Libvatrep (SAF312) is a potent, selective non-competitive inhibitor/antagonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), shows potential for treatment of ocular surface pain.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Libvatrep (SAF312) is a potent, selective non-competitive inhibitor/antagonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), shows potential for treatment of ocular surface pain.
SAF312 is >150-fold selective for TRPV1 when tested against a panel of 18 TRP channels.
SAF312 inhibited capsaicin, low pH 2-(n-morpholino)ethanesulfonic acid (MES, pH 5.5), anandamide (AEA), and N-arachidonoyl dopamine (NADA) stimulated human TRPV1 with IC50 values of 12, 16, 7.3 and 36 nM, respectively in a selective, non-competitive, and reversible manner.

物理化学性质&存储条件

分子量	305.337
分子式	C18H15N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(7-hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile

参考文献

1. Quint Medley, et al. ARVO Annual Meeting Abstract, June 2021. In-vitro and In-vivo pharmacology of SAF312 as a TRPV1 inhibitor for ocular surface pain.