Leuxinostat

Chemical Structure : Leuxinostat

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货号: PC-22782Not For Human Use, Lab Use Only.

Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells.

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生物&药学活性

Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells.
Leuxinostat shows good selectivity profile over HDAC1 (IC50 = 1203 nM), HDAC3 (IC50 = 2858 nM), HDAC5 (IC50 > 10000 nM), HDAC8 (IC50 = 2446 nM), HDAC10 (IC50 = 4811 nM), and HDAC11 (IC50 = 5570 nM).
Leuxinostat significantly rescued the expansion of HSPCs of FLT3-ITD overexpressing embryos on the HSPCs of the FLT3-ITD zebrafish model of AML.
Leuxinostat enhanced the gilteritinib-induced reduction in cmyb expression.
Leuxinostat showed anticancer activity and therapeutic potential in AML FLT3-ITD cells from AML patients.

物理化学性质&存储条件

分子量	356.38
分子式	C18H20N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hydroxy-4-((4-(4-nitrophenyl)piperazin-1-yl)methyl)benzamide

参考文献

1. Carullo G, et al. ACS Pharmacol Transl Sci. 2024 Jul 2;7(7):2125-2142.

Leuxinostat

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Leuxinostat

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