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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cathepsin-Leupeptin hemisulfate
Leupeptin hemisulfate

Chemical Structure : Leupeptin hemisulfate

CAS No.: 103476-89-7

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Leupeptin hemisulfate

货号: PC-45438Not For Human Use, Lab Use Only.

Leupeptin hemisulfate is a potent, reversible inhibitor of cysteine, serine, and threonine proteases, inhibits cathepsin B (Ki=6 nM), calpain (Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 uM), and kallikrein (Ki=19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.

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5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Leupeptin hemisulfate is a potent, reversible inhibitor of cysteine, serine, and threonine proteases, inhibits cathepsin B (Ki=6 nM), calpain (Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 uM), and kallikrein (Ki=19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.

物理化学性质&存储条件

分子量 475.59
分子式 C20H38N6O4 . 1/2H2SO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: ≥ 19 mg/mL
Chemical Name/SMILES

L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-, sulfate (2:1)

参考文献

1. Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.

2. Mehdi S. Trends Biochem Sci. 1991 Apr;16(4):150-3.

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