Leucettinib-92

Chemical Structure : Leucettinib-92

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货号: PC-20985Not For Human Use, Lab Use Only.

Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively.

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生物&药学活性

Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively.
Leucettinib-92 preferably targets CLK1, CLK2, CLK4, DYRK1A and DYRK1B on the Eurofins DiscovRx KinomeScan selectivity panel (468 kinases) at 1 uM.
Leucettinib-92 can penetrate cells and inhibits DYRK1A at low concentrations (from 0.1–0.3 μM) in cell models.

物理化学性质&存储条件

分子量	378.49
分子式	C21H22N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1NC(NC23CC4CC(C3)CC(C4)C2)=N/C1=C\C5=CC=C6N=CSC6=C5

参考文献

1. Emmanuel Deau, et al. J Med Chem. 2023 Jul 24. doi: 10.1021/acs.jmedchem.3c00884.

Leucettinib-92

生物&药学活性

物理化学性质&存储条件

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Leucettinib-92

生物&药学活性

物理化学性质&存储条件

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