Leucettine L41 |CAS:1112978-84-3 Probechem Biochemicals

Chemical Structure : Leucettine L41

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Leucettine L41 (CLK inhibitor L41)

货号: PC-61025Not For Human Use, Lab Use Only.

Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.

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生物&药学活性

Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
Leucettine L41 inhibits the phosphorylation of serine/arginine-rich proteins (SRp), a family of proteins regulating pre-RNA splicing, modulates alternative pre-mRNA splicing in cell-based reporting system.
Leucettine L41 induces mTOR-dependent autophagy, prevents Aβ25-35-induced memory impairments and neurotoxicity in the mouse hippocampus.

物理化学性质&存储条件

分子量	307.309
分子式	C17H13N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5Z)-5-(1,3-Benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-4H-imidazol-4-one

参考文献

1. Fant X, et al. Mol Pharmacol. 2014 Mar;85(3):441-50.

2. Naert G, et al. Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82.

3. Debdab M, et al. J Med Chem. 2011 Jun 23;54(12):4172-86.

4. Tahtouh T, et al. J Med Chem. 2012 Nov 8;55(21):9312-30.

Leucettine L41 (CLK inhibitor L41)

生物&药学活性

物理化学性质&存储条件

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Leucettine L41 (CLK inhibitor L41)

生物&药学活性

物理化学性质&存储条件

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