Chemical Structure : Lethal toxin inhibitor DN1
CAS No.:
325990-63-4
Lethal toxin inhibitor DN1
货号: PC-35825Not For Human Use, Lab Use Only.
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively.
DN1 protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation.
DN1 also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.
物理化学性质&存储条件
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分子量
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257.268
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分子式
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C14H12FN3O
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20 °C 12 个月; 4°C 6 个月
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- 配置液
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-80 °C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-fluoro- N'-[1-(2-pyridinyl)ethylidene]benzohydrazide
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参考文献
1. Hartmann S, et al. ACS Infect Dis. 2018 Nov 5. doi: 10.1021/acsinfecdis.8b00231.
