Letermovir (AIC246)

Chemical Structure : Letermovir

CAS No.: 917389-32-3

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货号: PC-73324Not For Human Use, Lab Use Only.

Letermovir (AIC246) is a potent anti-cytomegalovirus (CMV) compound, exhibits very potent in vitro antiviral activity aginst different HCMV laboratory strains (EC50=3-5 nM), through a specific antiviral mechanism that involves the viral terminase.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Letermovir (AIC246) is a potent anti-cytomegalovirus (CMV) compound, exhibits very potent in vitro antiviral activity aginst different HCMV laboratory strains (EC50=3-5 nM), through a specific antiviral mechanism that involves the viral terminase.
Letermovir (AIC246) interferes with HCMV DNA cleavage/packaging via a molecular mechanism that is distinct from that of other compound classes known to target the viral terminase.
Letermovir (AIC246) exhibits excellent in vitro inhibitory activity against HCMV laboratory strains and clinical isolates, retains activity against ganciclovir-resistant viruses, is well tolerated in different cell types.
Letermovir (AIC246) exerts a potent in vivo efficacy in a mouse xenograft model.

物理化学性质&存储条件

分子量	572.561
分子式	C29H28F4N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(8-Fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid

参考文献

1. Lischka P, et al. Antimicrob Agents Chemother. 2010 Mar;54(3):1290-7.

2. Kaul DR, et al. Am J Transplant. 2011 May;11(5):1079-84.

3. Marschall M, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):1135-7.

4. Goldner T, et al. J Virol. 2011 Oct;85(20):10884-93.