Letaplimab | Anti-CD47 mAb | Probechem Biochemicals

Chemical Structure : Letaplimab

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Letaplimab (IBI 188)

货号: PC-38830Not For Human Use, Lab Use Only.

Letaplimab (IBI 188) is a CD47 blocking monoclonal antibody that specifically block the CD47-SIRP-α axis, which transduces the "don't eat me" signal to macrophages.

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生物&药学活性

Letaplimab (IBI 188) is a CD47 blocking monoclonal antibody that specifically block the CD47-SIRP-α axis, which transduces the "don't eat me" signal to macrophages.
Letaplimab (IBI 188) demonstrated the pro-phagocytosis ability in in vitro phagocytosis assays.
Letaplimab (IBI 188) treatment upregulated cell movement- and inflammation-related genes in macrophages in in vivo cancer models.
Letaplimab (IBI 188) demonstrated synergistic effect combined with anti-CD20 therapeutic antibody, which depends on antibody-dependent cellular cytotoxicity/phagocytosis (ADCC/ADCP).
Isotype: IgG4-kappa.
Anti-[human CD47 (integrin associated protein, IAP, MER6, OA3)], human monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Haiqing Ni, et al. Cancer Immunol Immunother. 2022 Feb;71(2):353-363.

Letaplimab (IBI 188)

生物&药学活性

物理化学性质&存储条件

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Letaplimab (IBI 188)

生物&药学活性

物理化学性质&存储条件

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