Lesogaberan |CAS:344413-67-8 Probechem Biochemicals

Chemical Structure : Lesogaberan

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Lesogaberan (AZD-3355, AZD3355)

货号: PC-62764Not For Human Use, Lab Use Only.

Lesogaberan (AZD-3355) is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM).

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生物&药学活性

Lesogaberan (AZD-3355) is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM).
Lesogaberan (AZD-3355) potently stimulates recombinant human GABAB receptors and inhibits transient lower esophageal sphincter relaxation (TLESR) through a peripheral mode of action in vivo, shows potential for treatment of GERD.

物理化学性质&存储条件

分子量	141.082
分子式	C3H9FNO2P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((R)-3-Amino-2-fluoropropyl)phosphinic acid

参考文献

1. Lehmann A, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):504-12.

2. Brändén L, et al. Eur J Pharmacol. 2010 May 25;634(1-3):138-41.

3. Alstermark C, et al. J Med Chem. 2008 Jul 24;51(14):4315-20.

Lesogaberan (AZD-3355, AZD3355)

生物&药学活性

物理化学性质&存储条件

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Lesogaberan (AZD-3355, AZD3355)

生物&药学活性

物理化学性质&存储条件

参考文献

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