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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-URAT1-Lesinurad
Lesinurad

Chemical Structure : Lesinurad

CAS No.: 878672-00-5

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Lesinurad (RDEA594, RDEA-594)

货号: PC-20286Not For Human Use, Lab Use Only.

Lesinurad (RDEA594) is a potent selective urate anion transporter 1 (URAT1) inhibitor with IC50 of 3.5 and 81 µM for human and rat URAT1, respectively.

规格 价格 库存 数量
10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg ￥2480 In stock
250 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lesinurad (RDEA594) is a potent selective urate anion transporter 1 (URAT1) inhibitor with IC50 of 3.5 and 81 µM for human and rat URAT1, respectively.
Lesinurad (RDEA594) decreases uptake of urate by MDCK cells transfected with human URAT1.
Lesinurad (80 mg/kg) decreases serum levels of uric acid and urea nitrogen in a rat model of gout.

物理化学性质&存储条件

分子量 404.28
分子式 C17H14BrN3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid

参考文献

1. Miner JN, et al. Arthritis Res Ther. 2016 Oct 3;18(1):214.

2. Dalbeth N, et al. Arthritis Rheumatol. 2017 Sep;69(9):1903-1913.

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