MIN-102 (Leriglitazone) | PPARγ agonist | Probechem Biochemicals

Chemical Structure : Leriglitazone

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Leriglitazone (MIN-102, MIN102)

货号: PC-49255Not For Human Use, Lab Use Only.

MIN-102 (Leriglitazone) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with a potential best-in-class profile indicated for CNS diseases.

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生物&药学活性

MIN-102 (Leriglitazone) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with a potential best-in-class profile indicated for CNS diseases.
MIN-102 (Leriglitazone) increases frataxin levels and mitochondrial markers in FRDA models.
MIN-102 (Leriglitazone) protects from neurodegeneration by improving mitochondrial function.
MIN-102 (Leriglitazone) prevents lipid droplets formation in frataxin-deficient cardiomyocytes.
MIN-102 (Leriglitazone) rescues the motor function deficit of the YG8sR mice.
MIN-102 (Leriglitazone) emerges as a potential therapeutic agent for Friedreich Ataxia.

物理化学性质&存储条件

分子量	372.439
分子式	C19H20N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[[4-[2-[5-(1-Hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

参考文献

1. Laura Rodríguez-Pascau, et al. Neurobiol Dis. 2021 Jan;148:105162.

Leriglitazone (MIN-102, MIN102)

生物&药学活性

物理化学性质&存储条件

参考文献

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Leriglitazone (MIN-102, MIN102)

生物&药学活性

物理化学性质&存储条件

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