Legumain inhibitor 38u | Legumain inhibitor | Probechem Biochemicals

Chemical Structure : Legumain inhibitor 38u

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Legumain inhibitor 38u (AEP inhibitor 38u)

货号: PC-20812Not For Human Use, Lab Use Only.

Legumain inhibitor 38u is a selective inhibitor of asparagine endopeptidase (AEP, Legumain) with IC50 of 160 nM, inhibits cancer metastasis.

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生物&药学活性

Legumain inhibitor 38u is a selective inhibitor of asparagine endopeptidase (AEP, Legumain) with IC50 of 160 nM, inhibits cancer metastasis.
Legumain inhibitor 38u displays >1000-fold selectivity over other related major cysteine proteases (cathepsin-L, cathepsin-S, caspase-3 and caspase-8, all IC50s >150 uM).
Legumain inhibitor 38u blocks cancer cell invasion without impinging on the cell viability, Legumain inhibitor 38u (2 uM) significantly inhibits invasion of highly metastatic human breast cancer cell lines.
Legumain inhibitor 38u (3-10 mg/kg, oral gavage, 42 days) completely prevents breast-to-lung metastasis in vivo, does not exhibit toxic effects in mice.
Legumain inhibitor 38u inhibits AEP cleavage of MMP-2 in vitro and in vivo.

物理化学性质&存储条件

分子量	240.28
分子式	C9H12N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1CC)N(C)C2=C(N(C)C(S)=N2)C1=O

参考文献

1. Qi Qi, et al. J Med Chem. 2017 Sep 14;60(17):7244-7255.

Legumain inhibitor 38u (AEP inhibitor 38u)

生物&药学活性

物理化学性质&存储条件

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Legumain inhibitor 38u (AEP inhibitor 38u)

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物理化学性质&存储条件

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