Ledipasvir (GS-5885) | HCV NS5A inhibitor | Probechem Biochemicals

Chemical Structure : Ledipasvir

CAS No.: 1256388-51-8

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Ledipasvir (GS-5885, GS5885)

货号: PC-21354Not For Human Use, Lab Use Only.

Ledipasvir (GS-5885) is a potent, selective and oral HCV NS5A inhibitor with EC50 of 31 pM and 4 pM against GT1a and GT1b, respectively.

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50 mg	￥1780	In stock
100 mg	￥2880	In stock
200 mg	￥4280	In stock
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生物&药学活性

Ledipasvir (GS-5885) is a potent, selective and oral HCV NS5A inhibitor with EC50 of 31 pM and 4 pM against GT1a and GT1b, respectively.
Ledipasvir (GS-5885) produces a rapid >3 log viral load reduction in monotherapy at oral doses of 3 mg or greater with once-daily dosing in genotype 1a HCV-infected model.

物理化学性质&存储条件

分子量	889.02
分子式	C49H54F2N8O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl ((S)-1-((S)-6-(5-(9,9-difluoro-7-(2-((1R,3S,4S)-2-((methoxycarbonyl)-L-valyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-6-yl)-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate

参考文献

1. Link JO, et al. J Med Chem. 2014 Mar 13;57(5):2033-46.

2. Wong KA, et al. Antimicrob Agents Chemother. 2013 Dec;57(12):6333-40.

Ledipasvir (GS-5885, GS5885)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ledipasvir (GS-5885, GS5885)

生物&药学活性

物理化学性质&存储条件

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