Lck inhibitor C8863 |CAS:213743-31-8 Probechem Biochemicals

Chemical Structure : Lck inhibitor C8863

CAS No.: 213743-31-8

加入收藏

Lck inhibitor C8863 (C8863;RK-24466;KIN 001-51)

货号: PC-35738Not For Human Use, Lab Use Only.

Lck inhibitor C8863 (C8863, RK-24466, KIN 001-51) is a potent, selective Lck inhibitor, inhibits Lck (64-509) and LckCD isoforms with IC50 of <1 nM and < 2 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Lck inhibitor C8863 (C8863, RK-24466, KIN 001-51) is a potent, selective Lck inhibitor, inhibits Lck (64-509) and LckCD isoforms with IC50 of <1 nM and < 2 nM.
C8863 displays high selectivity for Lck over a range of receptor, non-receptor tyrosine kinases and seronine/threonine kinases.
C8863 significantly inhibits both VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and ERK pathways, and significantly decreases the expression of PCNA, cyclin D1 and pRb.
C8863 interferes with hESC-derived ECs with IC50 of 2.02 uM.

物理化学性质&存储条件

分子量	370.456
分子式	C23H22N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

参考文献

1. Otten C, et al. EMBO Mol Med. 2018 Oct;10(10). pii: e9155.

2. Seo HH, et al. Eur J Pharmacol. 2017 Mar 5;798:35-42.

3. Vazão H, et al. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3022-E3031.

Lck inhibitor C8863 (C8863;RK-24466;KIN 001-51)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Lck inhibitor C8863 (C8863;RK-24466;KIN 001-51)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.