Lazucirnon (ALK4290) | CCR3 antagonist | Probechem Biochemicals

Chemical Structure : Lazucirnon

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Lazucirnon (AKST4290, ALK4290)

货号: PC-38366Not For Human Use, Lab Use Only.

Lazucirnon (KST4290, ALK4290) is a small molecule, orally active inhibitor against CCR3, the natural receptor for chemokine eotaxin, decreases inflammatory cytokines in preclinical models.

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生物&药学活性

Lazucirnon (KST4290, ALK4290) is a small molecule, orally active inhibitor against CCR3, the natural receptor for chemokine eotaxin, decreases inflammatory cytokines in preclinical models.
Lazucirnon (KST4290, ALK4290) blocks eotaxin from binding to its G-protein coupled receptor (GPCR) CCR3.
CCR3 plays an important modulatory role in inflammation, immune cell recruitment, and neovascularization, processes important for the pathogenesis of wet age-related macular degeneration (wet AMD) and other neurological and immunological diseases.

物理化学性质&存储条件

分子量	512.051
分子式	C27H34ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(1-(1-(4-chloro-3-methylbenzyl)piperidin-4-yl)-5-oxopyrrolidine-2-carboxamido)-N,N,6-trimethylisonicotinamide

参考文献

1. Patent US20130261153A1.

Lazucirnon (AKST4290, ALK4290)

生物&药学活性

物理化学性质&存储条件

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Lazucirnon (AKST4290, ALK4290)

生物&药学活性

物理化学性质&存储条件

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