Lazertinib (YH25448, GNS-1480) | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : Lazertinib

CAS No.: 1903008-80-9

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Lazertinib (YH 25448, YH25448, GNS-1480, GNS1480)

货号: PC-60519Not For Human Use, Lab Use Only.

Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations.
Lazertinib shows the beneficial for the NSCLC with brain metastasis.

物理化学性质&存储条件

分子量	554.66
分子式	C30H34N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide

参考文献

1. Patent US20160102076 A1.

2. Yun J, et al. Clin Cancer Res. 2019 Jan 22. pii: clincanres.2906.2018. doi: 10.1158/1078-0432.CCR-18-2906.

Lazertinib (YH 25448, YH25448, GNS-1480, GNS1480)

生物&药学活性

物理化学性质&存储条件

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Lazertinib (YH 25448, YH25448, GNS-1480, GNS1480)

生物&药学活性

物理化学性质&存储条件

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