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首页-小分子抑制剂&激动剂-Others-Other Targets-Latrunculin A
Latrunculin A

Chemical Structure : Latrunculin A

CAS No.: 76343-93-6

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Latrunculin A (LAT-A)

货号: PC-27618Not For Human Use, Lab Use Only.

Latrunculin A (LAT-A) is a natural compound isolated from red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor, binds to actin monomers and inhibits polymerization of actin with Kd of 0.1, 0.4, 4.7 and 0.19 uM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively.

规格 价格 库存 数量
100 ug ￥2780 In stock
500 ug ￥5980 In stock
1 mg Get quote
5 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Latrunculin A (LAT-A) is a natural compound isolated from red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor, binds to actin monomers and inhibits polymerization of actin with Kd of 0.1, 0.4, 4.7 and 0.19 uM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively.
Latrunculin A is a potent inhibitor of the microfilament-mediated processes of fertilization and early development in sea urchins and in mice.
Latrunculin A is a potent inhibitor of phagocytosis by macrophages.
Latrunculin A is an inhibitor of actin assembly.

物理化学性质&存储条件

分子量 421.55
分子式 C22H31NO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-((1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)thiazolidin-2-one

参考文献

1. de Oliveira CA, et al. Life Sci. 1988;43(22):1825-30.

2. Schatten G, et al. Exp Cell Res. 1986 Sep;166(1):191-208.

3. Allison DW, et al. J Neurosci. 1998 Apr 1;18(7):2423-36.

4. Mehta D, et al. J Physiol. 1999 Sep 15;519 Pt 3(Pt 3):829-40.

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