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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-Lasmiditan
Lasmiditan

Chemical Structure : Lasmiditan

CAS No.: 439239-90-4

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Lasmiditan (COL-144, LY573144)

货号: PC-25707Not For Human Use, Lab Use Only.

Lasmiditan (COL-144, LY573144) is a high-affinity, highly selective serotonin 5-HT1F receptor agonist with Ki of 2.21 nM, >470-fold selective over 5-HT(1B) and 5-HT(1D) receptors.

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10 mg ￥2480 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lasmiditan (COL-144, LY573144) is a high-affinity, highly selective serotonin 5-HT1F receptor agonist with Ki of 2.21 nM, >470-fold selective over 5-HT(1B) and 5-HT(1D) receptors.

物理化学性质&存储条件

分子量 377.37
分子式 C19H18F3N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide

参考文献

1. Nelson DL, et al. Cephalalgia. 2010 Oct;30(10):1159-69.

2. Ferrari MD, et al. Cephalalgia. 2010 Oct;30(10):1170-8.

3. Färkkilä M, et al. Lancet Neurol. 2012 May;11(5):405-13.

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