Laquinimod (ABR-215062) |CAS:248281-84-7 Probechem Biochemicals

Chemical Structure : Laquinimod

CAS No.: 248281-84-7

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Laquinimod (ABR-215062, ABR215062)

货号: PC-43319Not For Human Use, Lab Use Only.

Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE).

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE).
Laquinimod (ABR-215062) dose-dependently reduces the incidence of EAN, ameliorated clinical signs and inhibited P0 peptide 180-199-specific T cell responses as well as also the decreased inflammation and demyelination in the peripheral nerves.
Laquinimod (ABR-215062) shows improved potency and superior toxicological profile compared to the lead compound Roquinimex (Linomide).

物理化学性质&存储条件

分子量	356.8029
分子式	C19H17ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Quinolinecarboxamide, 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-

参考文献

1. Zou LP, et al. Neuropharmacology. 2002 Apr;42(5):731-9.

2. Brunmark C, et al. J Neuroimmunol. 2002 Sep;130(1-2):163-72.

3. Jönsson S, et al. J Med Chem. 2004 Apr 8;47(8):2075-88.

4. Polman C, et al. Neurology. 2005 Mar 22;64(6):987-91.

Laquinimod (ABR-215062, ABR215062)

生物&药学活性

物理化学性质&存储条件

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Laquinimod (ABR-215062, ABR215062)

生物&药学活性

物理化学性质&存储条件

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