Lanperisone |CAS:116287-14-0 Probechem Biochemicals

Chemical Structure : Lanperisone

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Lanperisone (NK 433)

货号: PC-62036Not For Human Use, Lab Use Only.

Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion.

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1 g		Get quote

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生物&药学活性

Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion; shows potent and selective activity against K-rasG12D MEFs with IC50 of 4 uM in the CTG viability assay; causes a large population of cells with sub-2N DNA content, induces oxidative stress, but not in wild-type MEFs; suppresses the growth of K-ras-driven tumors without overt toxicity in mice; orally bioactive.

物理化学性质&存储条件

分子量	285.305
分子式	C15H18F3NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-2-methyl-3-pyrrolidin-1-yl-1-[4-(trifluoromethyl)phenyl]propan-1-one

参考文献

1. Shaw AT, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8773-8.

2. Sakitama K, et al. Eur J Pharmacol. 1997 Oct 22;337(2-3):175-87.

3. Glasauer A, et al. Biochem Pharmacol. 2014 Nov 1;92(1):90-101.

Lanperisone (NK 433)

生物&药学活性

物理化学性质&存储条件

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Lanperisone (NK 433)

生物&药学活性

物理化学性质&存储条件

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