Lanabecestat (AZD-3293, LY-3314814) | BACE1 inhibitor

Chemical Structure : Lanabecestat

CAS No.: 1383982-64-6

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Lanabecestat (AZD-3293, LY-3314814, LY3314814, AZD3293)

货号: PC-60045Not For Human Use, Lab Use Only.

Lanabecestat (AZD-3293, LY-3314814) is a potent, orally active and brain-permeable BACE1 inhibitor with Ki of 0.4 nM.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Lanabecestat (AZD-3293, LY-3314814) is a potent, orally active and brain-permeable BACE1 inhibitor with Ki of 0.4 nM.
Lanabecestat (AZD-3293, LY-3314814) shows equipotency against hBACE2 (Ki=0.8 nM), >25,000- and >41,000-fold selectivity against cathepsin D and γ-secretase。
Lanabecestat (AZD-3293, LY-3314814) significantly reduces Aβ40, Aβ42, and sAβPPβ in mouse, guinea pig and dog, also shows in vitro potency in mouse and guinea pig primary cortical neuronal cells (IC50<1 nM)。
Lanabecestat (AZD-3293, LY-3314814) reduces cerebrospinal fluid (CSF) Aβ1-40 and Aβ1-42 in clinical trails.

物理化学性质&存储条件

分子量	412.537
分子式	C26H28N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

参考文献

1. Eketjäll S, et al. J Alzheimers Dis. 2016;50(4):1109-23.

2. Sims JR, et al. J Prev Alzheimers Dis. 2017;4(4):247-254.

Lanabecestat (AZD-3293, LY-3314814, LY3314814, AZD3293)

生物&药学活性

物理化学性质&存储条件

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Lanabecestat (AZD-3293, LY-3314814, LY3314814, AZD3293)

生物&药学活性

物理化学性质&存储条件

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