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Lactacystin

Chemical Structure : Lactacystin

CAS No.: 133343-34-7

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Lactacystin

货号: PC-24468Not For Human Use, Lab Use Only.

Lactacystin is a potent, orally active, irreversible, cell-permeable, specific proteasome inhibitor (IC50=4.8 uM), also inhibits the lysosomal enzyme cathepsin A, inhibits cell cycle progression and induces neurite outgrowth in murine neuroblastoma cell line.

规格 价格 库存 数量
100 ug ￥1580 In stock
250 ug ￥2580 In stock
500 ug ￥4280 In stock
1 mg Get quote
5 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lactacystin is a potent, orally active, irreversible, cell-permeable, specific proteasome inhibitor (IC50=4.8 uM), also inhibits the lysosomal enzyme cathepsin A, inhibits cell cycle progression and induces neurite outgrowth in murine neuroblastoma cell line.

物理化学性质&存储条件

分子量 376.42
分子式 C15H24N2O7S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Acetyl-S-((2R,3S,4R)-3-hydroxy-2-((S)-1-hydroxy-2-methylpropyl)-4-methyl-5-oxopyrrolidine-2-carbonyl)-L-cysteine

参考文献

1. Omura S, et al. J Antibiot (Tokyo). 1991 Jan;44(1):113-6.

2. Oda K, et al. Biochem Biophys Res Commun. 1996 Feb 27;219(3):800-5.

3. Fenteany G, et al. Science. 1995 May 5;268(5211):726-31.

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