Labuxtinib (EVT-8565072, THB335) | c-Kit inhibitor | Probechem Biochemicals

Chemical Structure : Labuxtinib

CAS No.: 1426449-01-5

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Labuxtinib (EVT-8565072, THB335, THB-335)

货号: PC-23095Not For Human Use, Lab Use Only.

Labuxtinib (EVT-8565072, THB335) is an orally available, potent, and highly selective wild-type KIT inhibitor with IC50 of 5 nM.

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10 mg	￥4580	In stock
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生物&药学活性

Labuxtinib (EVT-8565072, THB335) is an orally available, potent, and highly selective wild-type KIT inhibitor with IC50 of 5 nM.

Labuxtinib inhibits SCF-dependent and PDGF-dependent cell proliferation, and blocks the proliferation of cells dependent on c-Kit or PDGFR signaling pathways.

Labuxtinib depletes skin mast cells and significantly alleviates anaphylactic shock responses in vivo.

物理化学性质&存储条件

分子量	377.38
分子式	C20H16FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

参考文献

1. Patent WO2013033070 A1 2013-03-07.

Labuxtinib (EVT-8565072, THB335, THB-335)

生物&药学活性

物理化学性质&存储条件

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Labuxtinib (EVT-8565072, THB335, THB-335)

生物&药学活性

物理化学性质&存储条件

参考文献

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