LYN-1604 |CAS:2088939-99-3 Probechem Biochemicals

Chemical Structure : LYN-1604

CAS No.: 2088939-99-3

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LYN-1604 (LYN1604)

货号: PC-63085Not For Human Use, Lab Use Only.

LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells), displays a good effect on ULK1 activation with an EC50 of 18.94 nM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells), displays a good effect on ULK1 activation with an EC50 of 18.94 nM.
LYN-1604 induces cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells.
LYN-1604 induces cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
LYN-1604 inhibits the tumor growth of xenograft TNBC.

物理化学性质&存储条件

分子量	584.626
分子式	C33H43Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-

参考文献

1. Zhang L, et al. Chem Sci. 2017 Apr 1;8(4):2687-2701.

2. Ouyang L, et al. Autophagy. 2017 Apr 3;13(4):777-778.

LYN-1604 (LYN1604)

生物&药学活性

物理化学性质&存储条件

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LYN-1604 (LYN1604)

生物&药学活性

物理化学性质&存储条件

参考文献

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