Cintirorgon (LYC-55716) | RORγ agonist | Probechem Biochemicals

Chemical Structure : LYC-55716

CAS No.: 2055536-64-4

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LYC-55716 (LYC55716, Cintirorgon)

货号: PC-63532Not For Human Use, Lab Use Only.

Cintirorgon (LYC-55716) is a potent, selective, and orally bioavailable Retinoic acid Receptor-related orphan receptor-γ (RORγ) agonist with FRET EC50 of 13 nM.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3780	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

Cintirorgon (LYC-55716) is a potent, selective, and orally bioavailable Retinoic acid Receptor-related orphan receptor-γ (RORγ) agonist with FRET EC50 of 13 nM.

LYC-55716 displays high selectivity over other NRs, including RORα and RORβ (EC50>10 uM).
LYC-55716 modulates expression of genes that promote immune responses, reduces PD-1 expression in vitro and in vivo after adoptive cell transfer, relieves PD-1/PD-L1 inhibition of proliferation and IFNγ.|
LYC-55716 significantly augments anti-tumor activity of doxorubicin, results in immune-dependent decreased tumor growth and enhanced survival in preclinical models of cancer.

物理化学性质&存储条件

分子量	603.532
分子式	C27H23F6NO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid

参考文献

1. Garry Alan Weems, et al. Journal of Clinical Oncology 36, no. 4_suppl (February 1 2018) 67-67.

LYC-55716 (LYC55716, Cintirorgon)

生物&药学活性

物理化学性质&存储条件

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LYC-55716 (LYC55716, Cintirorgon)

生物&药学活性

物理化学性质&存储条件

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