LY900009 |CAS:209984-68-9 Probechem Biochemicals

Chemical Structure : LY900009

CAS No.: 209984-68-9

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LY900009 (LY 900009;LY-900009)

货号: PC-35276Not For Human Use, Lab Use Only.

LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein, inhibits Notch signalling in tumour cell lines and endothelial cells with IC50 of 0.005-20 nM.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein, inhibits Notch signalling in tumour cell lines and endothelial cells with IC50 of 0.005-20 nM.
LY900009 dose dependently inhibits Notch cleavage and induces apoptosis 24 h after a single 3 mg/kg oral dose in xenograft tumour models.
LY900009 also demonstrates inhibition of angiogenesis through formation of leaky vasculature.

物理化学性质&存储条件

分子量	409.486
分子式	C23H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-hydroxy-3-methyl-N-((S)-1-(((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide

参考文献

1. Pant S, et al. Eur J Cancer. 2016 Mar;56:1-9. doi: 10.1016/j.ejca.2015.11.021.

LY900009 (LY 900009;LY-900009)

生物&药学活性

物理化学性质&存储条件

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LY900009 (LY 900009;LY-900009)

生物&药学活性

物理化学性质&存储条件

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