LY500307 |CAS:533884-09-2 Probechem Biochemicals

Chemical Structure : LY500307

CAS No.: 533884-09-2

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LY500307 (LY-500307;LY 500307;Erteberel;SERBA-1)

货号: PC-35370Not For Human Use, Lab Use Only.

LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM, 12-fold higher affinity than ERα and exhibits 32-fold more functional potency.

规格	价格	库存
2 mg	￥2880	In stock
5 mg	￥3980	In stock
10 mg	￥5880	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM, 12-fold higher affinity than ERα and exhibits 32-fold more functional potency.
LY500307 reduces proliferation and induces apoptosis in GBM cells, enhances ERβ signaling and expression.
LY500307 modulates the expression of genes involved in cell cycle, cell death, survival, and DNA damage response.
LY500307 also sensitizes GBM cells to chemotherapeutic agents, reduces GBM progression in an orthotopic model.

物理化学性质&存储条件

分子量	282.339
分子式	C18H18O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aS,4R,9bR)-1,2,3,3a,4,9b-Hexahydro-4-(4-hydroxyphenyl)cyclopenta[c][1]benzopyran-8-ol

参考文献

1. Sareddy GR, et al. Sci Rep. 2016 Apr 29;6:24185.

2. Zhao L, et al. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681.

3. Reese JM, et al. Oncotarget. 2017 Oct 11;8(57):96506-96521.

LY500307 (LY-500307;LY 500307;Erteberel;SERBA-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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LY500307 (LY-500307;LY 500307;Erteberel;SERBA-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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