LY 392098 |CAS:211311-39-6 Probechem Biochemicals

Chemical Structure : LY 392098

CAS No.: 211311-39-6

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LY 392098 (LY-392098)

货号: PC-63023Not For Human Use, Lab Use Only.

LY 392098 is a selective, potent and centrally active positive allosteric modulator of AMPAR.

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5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
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生物&药学活性

LY 392098 is a selective, potent and centrally active positive allosteric modulator of AMPAR.
LY 392098 enhances glutamate (100 uM) stimulated ion influx through recombinant homomeric human AMPAR ion channels with EC50 of 1.77 uM (GluR1(i)), 0.22 uM (GluR2(i)), 0.56 uM (GluR2(o)), 1.89 uM (GluR3(i)) and 0.20 uM (GluR4(i).
LY 392098 enhances a dose-dependent manner responses to AMPA, potentiates the synaptic excitation of dentate granule cells following perforant path stimulation in vivo.

物理化学性质&存储条件

分子量	335.44
分子式	C18H22FNO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{2-[4-(2-fluorophenyl)phenyl]propyl}propane-2-sulfonamide

参考文献

1. Miu P, et al. Neuropharmacology. 2001 Jun;40(8):976-83.

2. Gates M, et al. Neuropharmacology. 2001 Jun;40(8):984-91.

3. Vandergriff J, et al. Neuropharmacology. 2001 Jun;40(8):1003-9.

LY 392098 (LY-392098)

生物&药学活性

物理化学性质&存储条件

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LY 392098 (LY-392098)

生物&药学活性

物理化学性质&存储条件

参考文献

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