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首页-小分子抑制剂&激动剂-GPCR-mGluR-LY367385
LY367385

Chemical Structure : LY367385

CAS No.: 198419-91-9

LY367385

货号: PC-23780Not For Human Use, Lab Use Only.

LY367385 is a potent, highly selective mGluR1 antagonis with IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, shows no activity against mGluR5.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY367385 is a potent, highly selective mGluR1 antagonis with IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, shows no activity against mGluR5.

物理化学性质&存储条件

分子量 209.20
分子式 C10H11NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-(Amino(carboxy)methyl)-3-methylbenzoic acid

参考文献

1. Sergueeva OA, et al. Neuropharmacology. 1993 Sep;32(9):933-5.

2. Eaton SA, et al. Eur J Pharmacol. 1993 Jan 15;244(2):195-7.

3. lark et al. Bioorg.Med.Chem.Lett. November 1997, 7 (21): 2777-2780.

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