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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-LY3526318
LY3526318

Chemical Structure : LY3526318

CAS No.: 1889218-34-1

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LY3526318 (LY-3526318)

货号: PC-23622Not For Human Use, Lab Use Only.

LY3526318 is an orally bioavailable, potent, and selective TRPA1 antagonist with limited penetration to the central nervous system, effectively blocks cinnamaldehyde-evoked activation of rat and human TRPA1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LY3526318 is an orally bioavailable, potent, and selective TRPA1 antagonist with limited penetration to the central nervous system, effectively blocks cinnamaldehyde-evoked activation of rat and human TRPA1.

物理化学性质&存储条件

分子量 556.47
分子式 C23H19F3N10O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(3-methyl-1-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-(2-(trifluoromethyl)pyrimidin-5-yl)pyridin-2-yl)propanamide

参考文献

1. Bamps D, et al. Clin Pharmacol Ther. 2023 Nov;114(5):1093-1103.

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