LY3522348 | Ketohexokinase (KHK) inhibitor | Probechem Biochemicals

Chemical Structure : LY3522348

CAS No.: 2568608-48-8

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LY3522348 (LY 3522348, LY-3522348)

货号: PC-21410Not For Human Use, Lab Use Only.

LY3522348 is a potent, highly selective, oral dual inhibitor of human ketohexokinase isoforms C and A (hKHK-C, hKHK-A) with IC50 of 20 nM and 24 nM, respectively.

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1 mg	￥1580	In stock
5 mg	￥3480	In stock
10 mg	￥5480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

LY3522348 is a potent, highly selective, oral dual inhibitor of human ketohexokinase isoforms C and A (hKHK-C, hKHK-A) with IC50 of 20 nM and 24 nM, respectively.
LY3522348 potently inhibits mouse KHK-A and KHK-C enzymes with IC50 of 14 nM and 20 nM, respectively, exhibits IC50 of 41 nM in cell assay expressing hKHK.
LY3522348 shows no concerning cross-reactivity in a panel of 468 kinases as well as common profiling targets such as hERG.
LY3522348 (30-100 mg/kg PO) displays a robust pharmacodynamic response in a mouse model of fructose metabolism.

物理化学性质&存储条件

分子量	409.42
分子式	C18H22F3N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[4-[2-[(2S)-2-Methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]pyrazol-1-yl]-1-piperazin-1-yl-ethanone

参考文献

1. Durham TB, et al. J Med Chem. 2023 Nov 22. doi: 10.1021/acs.jmedchem.3c01410.

LY3522348 (LY 3522348, LY-3522348)

生物&药学活性

物理化学性质&存储条件

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LY3522348 (LY 3522348, LY-3522348)

生物&药学活性

物理化学性质&存储条件

参考文献

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